Sorry, "no" to all your options. The response will just be lost. Even more, like you can read in the specifications:
3.3.6 Important notice on receive windows
An end-device shall not transmit another uplink message before it either has received a downlink message in the first or second receive window of the previous transmission, or the second receive window of the previous transmission is expired.
If there's any safety involved, then I'd say LoRa(WAN) is not a good match.